Obesity and Endocrine System: What is the Relationship?

By Wiki Healthier Staff

Obesity is a condition closely related to the functioning of the endocrine glands. Obese patients generally develop insulin resistance, although they do not normally suffer from hyperglycemia.

Obesity is a disease related to major abnormalities of the endocrine system. Hyperinsulinemia and insulin resistance are two of the most famous changes, although their mechanisms of action and clinical relevance are still unclear. Therefore, the relationship between obesity and the endocrine system is evident.

Obesity is defined as excess body fat. Its clinical management is complex and often offers poor results. Specifically, abdominal obesity, or central obesity, reflects the amount of visceral fat and is directly related to insulin resistance and cardiovascular events.

Obesity and excess weight cause a series of endocrine and metabolic changes. Most of the changes are believed to be secondary to obesity, as they can be induced by overeating and eliminated with weight loss. What is the relationship between obesity and the endocrine system? In the following lines, we will try to provide an answer.

The main glands of the endocrine system are the hypothalamus, the pituitary gland, the thyroid gland, the parathyroid glands, the pancreas, the adrenal glands and the gonads (male and ovarian testicles in female).

In certain situations, the endocrine glands secrete chemicals called hormones. These substances regulate a large number of cellular activities, such as:

  • increase.
  • metabolism.
  • developing.
  • sexual function.

obesity and endocrine pancreas

The quintessential introquinological alteration of obesity is increased insulin secretion. Obese patients have higher insulin concentrations. In particular, basal and integrated 24-hour insulin secretion is three to four times higher in obese subjects than in lean subjects.

Both obesity and type 2 diabetes mellitus are associated with insulin resistance. However, most insulin resistant subjects do not develop hyperglycemia. In summary, in obesity hyperinsulinism is quite common and insulin resistance is typical in situations of high weight gain.

Obesity and the pituitary gland

The pituitary gland, or pituitary, is one of the major endocrine glands in the body. In case of obesity, the most obvious amendment to the functioning of this gland is linked to the production of growth hormone or GH.

The secretion of this hormone depends mainly on the interaction between somatocrinin (GRH) and somatostatin (GIH). In case of obesity, there is a decrease in GH secretion.

Yes In children than in adults, the higher the body mass index, the smaller the response of growth hormone to different secretory stimuli. It has been seen that at a certain age for each body’s body mass index, or BMI, GH secretion decreases by up to 6%.

Obesity and the endocrine system: The gonads

It is first necessary to distinguish between the gonads, or ovaries, and the male gonads, the testicles. In case of obesity, in women a number of conditions precede metabolic abnormalities, such as pre-diabetes, diabetes and cardiovascular disease in women. These abnormalities include:

  • early Menarcha.
  • infertility.
  • polycystic ovary syndrome.
  • In other hands, at the end of a woman’s reproductive life, even the termination of ovarian function is related to the development of obesity. This is because menopause favors an increase in abdominal weight, which is associated with numerous adverse metabolic consequences.

    With respect to men, obesity is linked to a reduction in total testosterone. The pathogenic factors involved consist of a lower ability to bind sex hormone connecting globulin, but also of the amplitude of the LH or luteinizing hormone pulses and hyperestrogenemia.

    LH in man is the LH hormone that regulates the secretion of testosterone. Age in testicular cells and stimulates the production of testosterone.

    Obesity and adrenal glands

    Given the relationship between obesity, central fat distribution, and hypercortisolemia, many studies have attempted to verify whether cortisol plays an important role in the development of obesity in the general population.

    In obese women with abdominal fat distribution, urinary free cortisol levels are significantly higher. These results suggest iorractivity in the hypothalamus-Ipofysi-Futuey-Farety Exis.

    You may be interested in… Read more healthy symptoms of a hormonal imbalance

    If you have noticed changes in your body lately, you may be experiencing some symptoms of hormonal imbalance.